The neutron activation analysis as a primary method for determination of mass fraction of high number of elements was applied for investigation of their temporal and spatial distribution among edible mussels and oysters. It allowed to find levels of the 29 macro and microelements in soft tissues and 24 in shells of such molluscs. To compare the samples of wild and farmed mussels were collected...
The immunocytochemical staining and fluorescence microscopy was used to investigate the effects of radiosensitization by the cytosine arabinoside AraC on the induction and repair of DNA double-strand breaks (DSBs) in normal human dermal fibroblasts and human glioblastoma U87. Cells were irradiated with 1.25 Gy of Bragg peak protons (LET = 2 – 25 keV/μm) and accelerated nitrogen ions with doses...
Recreational zones play an important role in human life in urban environment. The activities of natural radionuclides and $^{137}$Cs were determined by low background γ-ray spectrometry in soil samples collected at two depths (0–5 and 5–20 cm) in 15 recreational zones of Moscow. The average activity concentrations of analyzed radionuclides were 519, 35.1, 29, 1.9 and 8.0 Bq/kg for $^{40}$K,...
The previously characterized viral channelrhodopsin VirChR1 shows the necessary characteristics of an optogenetic tool. It also shows a unique impermeability for Ca$^{2+}$ ions, presumably helping avoid the impact of calcium influx, which is useful for the neuroscientific applications of optogenetics. VirChR1’s ability to drive neural firing is compromised by the low ion conductance. To fix...
Alzheimer’s disease (AD) is a neurodegenerative disorder that is the sixth leading cause of death and the most common cause of brain dementia worldwide. Over the last years, representative advancements have been made in our understanding of AD by studying the molecular mechanisms underlying amyloid-β(Aβ) and tau proteins pathology.
In general, AD is characterized by the deposition of...
When treating cancer with proton beams, it is important to obtain flat dose plateau of the beam covering target volume where the tumor is located [1]. In the dynamic irradiation method, the beam energy is changed using range-shifter to create the Spread-out Bragg peak (SOBP) at the required distance. In this work, the relationship between Plexiglas range-shifter and Bragg peak position was...
Molecular dynamics (MD) modeling is often becoming a key tool for studying biophysical systems due to increasing computational power and software availability. The MD method makes it possible to study in detail the mobility of molecules, both of their main chains and side chains. As a result of modeling, a large amount of data is generated. The stream of data generated when running an MD...
The theranostics approach in nuclear medicine is based on the use of radiopharmaceuticals with similar chemical behavior, that enable both therapeutic and diagnostic applications with well managed kinetics and biodistribution in the body. As radionuclides are the active agents for such medicine, the most appropriate solution for the purpose is to use radioisotopes of the same chemical element,...
The problem of full-scale ground-based modeling of cosmic radiation using heavy ion accelerators for space radiobiology is very relevant. A new type of cosmic radiation simulator based on a $^{56}$Fe ion beam with an energy 1 GeV/n is proposed. The simulator uses rotating converters consisting of segmented targets of various thicknesses. This design ensures the uniformity of the fields of all...
