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In this paper, the production and spectroscopic investigation of Mercury and Radon isotopes was performed using complete fusion reactions neutron evaporation residues and multi-nucleon transfer reaction at the mass-separator MASHA. The MASHA setup is installed on the beam line of Cyclotron U-400M at Flerov Laboratory of Nuclear Reactions (FLNR) in Joint Institute for Nuclear Research (JINR), Dubna, Russia. The isotopes produced in complete fusion reactions $^{148}Sm(^{40}Ar,xn)^{188-x}Hg$, $^{166}Er(^{40}Ar,xn)^{206-x}Rn$ and multi-nucleon transfer reaction $^{48}Ca$ + $^{242}Pu$ were passed through the magneto-optical system of MASHA setup with charge state Q=+1 and were separated on the basis of their mass to charge ratio. For the detection of these isotopes, a position sensitive Si detector was used. Further, the experimental data obtained were analysed and spectroscopic investigations were carried out.