A mathematical model of tumor dynamics, taking into account nonlinear growth, immune control, diffusion and radiotherapy, is proposed. The equilibrium states of the tumor are studied and the conditions for its elimination with single and fractionated irradiation are obtained. For the three-dimensional spherically symmetric case, the features of the tumor volume change are studied.
The study of behavioral reactions, EEG and morphological changes in nerve tissue is essential to assess the risks of acute and long-term effects of radiation therapy for malignant tumors in the brain. This work presents the results of experiments to estimate the level of anxiety, exploratory and motor activity, working memory and EEG of rats after local single irradiation of the brain at a...
The study of neurobiological effects of accelerated protons is an important task in medical and space radiation biology. Proton irradiation of the body (e.g., as a result of solar proton events) can lead to a range of neurophysiological, hormonal, and morphological alterations in tissues, as well as shifts in microbiota composition. The relationship between these changes and disturbances of...
Radiation-induced impairments in memory and learning are associated to the death of neural stem cells (NSCs) in the dentate gyrus of the hippocampus [1, 2]. Three types of NSCs have been identified distinguished by their self-renewal rates: active cells, long-term self-renewing cells, and resting cells [3]. Additionally, has been established the coexistence of three NSC types — alpha, beta,...
In the study of molecular compounds, the most promising tool for analyzing atomic structures is a free electron laser [1]. This is due to the difficulties of analyzing molecules using other methods. There are several ways to study the structure of biomolecules, for example, the Sanger method. Such sequencing methods do not provide accurate results at the atomic level of research, while they...
The karyotypes of the majority of tumor cell lines are highly abnormal with numerical changes and rearranged chromosomes. We studied the chromosome complement and genetic stability of cultured human cells of different origins using the modern and advanced method of molecular cytogenetics Multicolor Fluorescence in situ Hybridization (mFISH). This method, applying chromosome-specific...
