A novel 111In production by irradiation of Sb target with high energy protons (600 MeV) for further Perturbed Angular Correlation measurements

Apr 16, 2019, 2:45 PM
15m
LIT, JINR

LIT, JINR

Oral Life Science Life Science

Speaker

Mrs Elena Kurakina (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia; Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology, Moscow, Russia)

Description

In present work, 3-step separation scheme using ion-exchange chromatography of 111In purification is performed. 1 g of Sb target was irradiated with 600 MeV protons at 1 µA current for 3 hours at the Phasotron facility (DNLP JINR). The activity of desired radionuclide at EOB equaled 53 MBq//µAh. The separation factor at each step was estimated to be 10^3. Along with 111In purification, 119mTe/117mSn separation is presented. 111In (T1/2= 2.8 d) is one of the most used radionuclides in diagnostics, also one of the most suitable isotopes for γγ-Perturbed Angular Correlation (PAC) measurements due to its parameters: t1/2 = 85 ns, I= +5/2, Q= +0.68, µ= -0.7656, cascade 171-245 keV [1]. γγ-PAC is a unique method in investigation of the local environment of the probe in liquids especially with a chelator in the system [2]. Moreover, required concentration of the probe is up to 10^(-12) mol/l which makes this technique very useful for measuring the precursors of the radiopharmaceuticals being used in Nuclear Medicine [3]. [1] A. Jancso et al., “TDPAC and β -NMR applications in chemistry and biochemistry,” J. Phys. G Nucl. Part. Phys., vol. 44, no. 6, p. 064003, 2017. [2] L. Hemmingsen and T. Butz, “Perturbed Angular Correlations of γ-rays (PAC) Spectroscopy,” Encycl. Inorg. Bioinorg. Chem., pp. 1–15, 2011. [3] D. V Filosofov, A. F. Novgorodov, O. I. Kochetov, N. A. Korolev, and N. A. Lebedev, “Investigation of the DTPA complex formations of indium and cadmium by a γγ - perturbed angular correlation method,” Jahresbericht, Inst. für Kernchemie, vol. 3, no. 20-02, 2004.

Primary author

Mrs Elena Kurakina (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia; Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology, Moscow, Russia)

Co-authors

Dr Atanas Velichkov (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia; Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia, Bulgaria) Dr Dimitr Karaivanov (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia; Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia, Bulgaria) Dr Dmitry Filosofov (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia) Dr Eldar Magomedbekov (Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology, Moscow, Russia) Dr Genko Marinov (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia) Ms Nargiza Temerbulatova (Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna, Russia) Dr Valery Radchenko (TRIUMF, Vancouver, Canada)

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