Speaker
Alexandr Bugai
(Joint Institute for Nuclear Research)
Description
JINR accelerators provide extensive capacity for multifaceted radiobiological research concerning basic problems of radiation genetics, molecular radiobiology, and radiation physiology, as well as a wide spectrum of practical issues, the most challenging ones being space radiobiology with special reference to manned interplanetary missions and the use of charged particles for the treatment of malignant tumors. Possible acute and delayed risks to the central nervous system (CNS) are accepted now as the most concerning in these fields. The aim of this lecture is to explain approaches for solving the problem of radiation-induced disorders in CNS. Particular emphasis will be given on principal difference of biological action between low-linear energy transfer (LET) radiation (X rays or gamma-rays) and high LET radiation (protons and heavy charged ions). Current progress in the experimental physiological and molecular biological studies in conjunction with theoretical results obtained by computer modelling techniques will be reviewed.
Primary author
Alexandr Bugai
(Joint Institute for Nuclear Research)
