Modeling the survival rate of a heterogeneous population of neural stem cells in response to irradiation with 56Fe particles

31 Oct 2024, 16:45
15m
134/4-406 (MLIT)

134/4-406

MLIT

20
Oral Mathematical Modeling and Computational Physics Life Science

Speaker

Artem Glebov (LRB)

Description

Some radiation-induced disorders characterized by memory and learning impairments are associated with a decrease in the number of neural stem cells (NSCs) in the dentate gyrus of the hippocampus after irradiation with 56Fe particles [1, 2]. There are several types of neural stem cells, which differ in their morphology and activation rate of division [3, 4]. At the same time, mathematical models that simulate the dynamics of neural stem cells death after irradiation assume the population of NSCs to be homogeneous [5, 6], that allows for long-term predictions of cell response, but not for short-term responses.

In order to improve the accuracy predicting changes in the neural stem cell population after radiation exposure we have developed a mathematical model that considers the heterogeneity of NSCs based on differences in activation rate of division. The model consists of eleven ordinary differential equations whose parameters were derived from an experiment of chronic intravital imaging to follow individual NSCs [4]. In results, we were able to replicate experimental data on NSCs survival at various time points after exposure to 56Fe particles with a dose of 1 Gy and linear energy transfer of 148 and 240 keV/μm [1, 2]. Further developing of mathematical models that simulate the dynamics of neural stem cells death after irradiation it will allow enhanced therapies for radiation-caused cognitive impairments.

  1. Rivera, Phillip D., et al. "Acute and fractionated exposure to high-LET 56Fe HZE-particle radiation both result in similar long-term deficits in adult hippocampal neurogenesis." Radiation research 180.6 (2013): 658-667.

  2. DeCarolis, Nathan A., et al. "56Fe particle exposure results in a long-lasting increase in a cellular index of genomic instability and transiently suppresses adult hippocampal neurogenesis in vivo." Life sciences in space research 2 (2014): 70-79.

  3. Martín‐Suárez, Soraya, et al. "Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus." Aging cell 18.4 (2019): e12958.

  4. Wu, Yicheng, et al. "Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus." Nature Aging 3.4 (2023): 380-390.
  5. Cacao, Eliedonna, and Francis A. Cucinotta. "Modeling heavy-ion impairment of hippocampal neurogenesis after acute and fractionated irradiation." Radiation research 186.6 (2016): 624-637.
  6. Glebov, A. A., E. A. Kolesnikova, and A. N. Bugay. "Analysis of the influence of dose-dependent effects of irradiation with heavy particles 12C, 28Si, and 56Fe on neurogenesis in adult C57BL/6J mice." Physics of Particles and Nuclei 55.4 (2024): 978-983.*

Primary author

Artem Glebov (LRB)

Co-authors

A.N Bugay (LRB, JINR) Elena Kolesnikova (JINR)

Presentation materials